Genomic studies of urothelial carcinoma have identified inactivation of tumor suppressor genes (e.g., TP53, ARID1A) and activation of oncogenes (e.g., FGFR3, PIK3CA). 3′ RACE is a useful method for identifying
Tumor tissue is a complex system with interactions between tumor cells and microenvironment cells. Spatial transcriptomics technology analyzes individual cell transcriptomes in tissues, revealing differences between tumor core and metastatic
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality globally. The standard methods for assessing MSI and dMMR are polymerase chain reaction (PCR) and 4-antibody immunohistochemistry (IHC).
The study isolated human pancreatic islet-derived mesenchymal stem cells (hPD-MSCs) from donor islets using lentiviral transduction of human telomerase reverse transcriptase. These cells were subsequently identified as adipogenic and osteogenic
To address food security challenges and climate change, the polyploid wild rice Oryza alta has been explored as a potential crop, although it suffers from seed shattering. We employed mesoporous
Magnetic nanoparticles (MNPs), due to their magnetic properties, can be activated by alternating magnetic field heating or unheated low frequency magnetic fields, thereby exerting intrinsic therapeutic effects or promoting drug
This study aims to perform a prenatal genetic diagnosis of a high-risk fetus with trisomy 7 identified by noninvasive prenatal testing (NIPT) and to evaluate the efficacy of different genetic
As the demand for WES increases and the cost of NGS decreases, WES, as a technique, requires a generous understanding of how experimental design can improve data interpretation and thus
IgG4-related disease (IgG4-RD) has complex clinical manifestations ranging from fibrosis and inflammation to deregulated metabolism. The molecular mechanisms underpinning these phenotypes are unclear. To investigate the transcriptomic changes in IgG4-RD
In this study, transcriptome sequencing of the whole fermentation course was perf ormed to explore the synthesis and regulation mechanism of AprE in B. licheniformis AQ. During the fermentation process,
