IgG4-related disease (IgG4-RD) has complex clinical manifestations ranging from fibrosis and inflammation to deregulated metabolism. The molecular mechanisms underpinning these phenotypes are unclear. To investigate the transcriptomic changes in IgG4-RD
In this study, transcriptome sequencing of the whole fermentation course was perf ormed to explore the synthesis and regulation mechanism of AprE in B. licheniformis AQ. During the fermentation process,
The purpose of this study was to compare the chloroplast genomes of T. sinskajae and T. monococcum accession k-20970 and clarify the phylogenetic relationships between einkorn wheats via GeneMind GenoLab M
Targeted genomic sequencing (TS) greatly benefits precision oncology by rapidly detecting genetic variations with better accuracy and sensitivity owing to its high sequencing depth. Multiple sequencing platforms and variant calling
Structural variations (SV) are critical genome changes affecting human diseases. Although many hybridization-based methods exist, evaluating SVs through next-generation sequencing (NGS) data is still necessary for broader research exploration. In
SARS-CoV-2 and influenza A viruses are similar in transmission and respiratory symptoms but differ in virulence, treatment and vaccine availability. Metagenomic nextgeneration sequencing (mNGS) does not depend on culture and
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often absent or at low levels in the cerebrospinal fluid (CSF) of patients with previous SARS CoV-2-associated Guillain-Barre syndrome (GBS). This has
The Omicron BA.5.2 variant of SARS-CoV-2 has undergone several evolutionary adaptations, leading to multiple subvariants. Rapid and accurate characterization of these subvariants is essential for effective treatment, particularly in critically
To study the molecular mechanisms responsible for inducing the spatial proliferation of malignant melanomas (MM), three-dimension (3D) spheroids were produced from several MM cell lines , and their 3D architectures
In this study, we measured cytotoxicity by several anti-tumor agents, cellular metabolism including mitochondrial and glycolytic functions by a Seahorse bio-analyzer, the physical properties, size and stiffness of the 3D
