Tumor tissue is a complex system with interactions between tumor cells and microenvironment cells. Spatial transcriptomics technology analyzes individual cell transcriptomes in tissues, revealing differences between tumor core and metastatic edge regions, and identifying prognostic gene expression patterns.
Researchers from Tomsk National Research Medical Center published a paper in Scientific Reports on using spatial transcriptomics to study early-onset tongue cancer, based on sequencing nine TSCC samples and two single-cell transcriptomics samples.
This study, based on GeneMind GenoLab M high-throughput sequencing platform, performed spatial transcriptomics sequencing on nine samples of tongue squamous cell carcinoma and single-cell transcriptomics sequencing on two of the samples. The study comprehensively uncovered the unique transcriptomic features and potential molecular mechanisms of early-onset tongue squamous cell carcinoma, providing valuable insights for further research and personalized treatment of this cancer.
