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Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease

IgG4-related disease (IgG4-RD) has complex clinical manifestations ranging from fibrosis and inflammation to deregulated metabolism. The molecular mechanisms underpinning these phenotypes are unclear. To investigate the transcriptomic changes in IgG4-RD patients, we performed transcriptome profiling of B cells isolated from HCs or IgG4-RD patients by using GeneMind GenoLab M sequencer. In this study, by using IgG4-RD patient peripheral blood mononuclear cells (PBMCs), IgG4-RD cell lines and Usp25 knockout mice, we show that ubiquitin-specific protease 25 (USP25) engages in multiple pathways to regulate fibrotic and inflammatory pathways that are characteristic to IgG4-RD.All together, our data suggest that USP25 is associated with fibrosis, inflammation, and metabolism of IgG4-RD patients, which serves as a potential diagnostic and therapeutic target.

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