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Ultra-high static magnetic fields cause immunosuppression through disrupting B-cell peripheral differentiation and negatively regulating BCR signaling

In the last few decades, SMF has been widely applied in medicine, such as magnetic resonance imaging (MRI), which is one of the most common clinical diagnostic equipment due to its powerful imaging capability. Higher magnetic field intensity of MRI has been pursued to increase the resolution and sensitivity while reducing exposure time. However, research on the side effects of high magnetic field is still very inadequate and the effects of SMF above 1 T (Tesla) on B cells have never been reported.

In this study, we using GenoLab M platform to do the RNA sequencing and gene enrichment analysis, the result showed that SMF stimulation also affects splenic B cells’ transcriptome and metabolic pathways. Together with other technology, our study suggests that ultra-high SMFs could disrupt B cell peripheral differentiation as well as negatively regulate BCR signaling and thereby cause immunosuppression.

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