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Inhibition of Hepatitis B Virus (HBV) replication and antigen expression byBrucea javanica(L.) Merr. oil emulsion

Hepatitis B virus (HBV) is a major global health problem and is ranked amog the top 10 infectious diseases causing death. The seeds of Brucea javanica (L.) Merr. (BJ) have been traditionally used to treat various types of cancers for many years in China. In this study, we systematically investigated a BJ oil emulsion (BJOE) produced from BJ seeds with the purpose of evaluating its antiviral effect against hepatitis B virus (HBV).

In this study, IL-6 was found which could be stimulated by BJOE and then inhibited HBV replication. The total RNA of HepG2 cells with or without BJOE treatment sequenced on GenoLab M platform, up-regulation of IL-6 was confirmed by transcriptome sequencing. To sum up, we find IL-6 can effectively inhibit HBV replication via the reduction of viral transcripts/core proteins and of HBV genome-containing nucleocapsids formation.

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